On-Going Clinical Studies

1. Project 2: Strategies for Reducing Nicotine Content in Cigarettes

Phase III – 1,250 Subjects
ClinicalTrials.gov Identifier:  NCT02139930
Sponsor:  University of Pittsburgh
Collaborator:  National Institute on Drug Abuse (NIDA)

2. Facilitating Smoking Cessation With Reduced Nicotine Cigarettes

ClinicalTrials.gov Identifier:  NCT02796391
Sponsor:  H. Lee Moffitt Cancer Center and Research Institute
Collaborator:  James and Esther King Biomedical Research Program

3. Novel Approaches to Reducing Tobacco Related Harm

ClinicalTrials.gov Identifier:  NCT02600273
Sponsor:  Duke University
Collaborator:  National Institute of Allergy and Infectious Diseases (NIAID)

4. Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

ClinicalTrials.gov Identifier:  NCT02870218
Sponsor:  Rose Research Center, LLC
Collaborators:  National Institutes of Health (NIH) and Food and Drug Administration (FDA)

5. Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

ClinicalTrials.gov Identifier:  NCT02599571
Sponsor:  Duke University
Collaborators:  Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Food and Drug Administration (FDA), and University of Pittsburgh

6. Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers

ClinicalTrials.gov Identifier:  NCT02587312
Sponsor:  Brown University
Collaborator:  National Cancer Institute (NCI)

7. Manipulating Tobacco Constituents in Female Menthol Smokers

ClinicalTrials.gov Identifier:  NCT02048852
Sponsor:  University of Connecticut Health Center
Collaborator:  National Institute on Drug Abuse (NIDA)

8. Manipulating Tobacco Constituents in Male Menthol Smokers

ClinicalTrials.gov Identifier:  NCT02592772
Sponsor:  University of Connecticut Health Center
Collaborator:  National Institute on Drug Abuse (NIDA)

9. Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women

ClinicalTrials.gov Identifier:  NCT02250534
Sponsor:  University of Vermont
Collaborators:  National Institute on Drug Abuse (NIDA) and Johns Hopkins University

10. Project 1, Study 2: The Combined Impact of Nicotine Replacement and Spectrum Cigarettes

ClinicalTrials.gov Identifier:  NCT02301325
Sponsor:  University of Pittsburgh

11. Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers

ClinicalTrials.gov Identifier:  NCT02250664
Sponsor:  University of Vermont
Collaborators:  National Institute on Drug Abuse (NIDA) and Johns Hopkins University

12. Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders

ClinicalTrials.gov Identifier:  NCT02232737
Sponsor:  Brown University
Collaborator:  University of Vermont

13. Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status

ClinicalTrials.gov Identifier:  NCT01928719
Sponsor:  Milton S. Hershey Medical Center
Collaborator:  George Washington University

14. Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders

ClinicalTrials.gov Identifier:  NCT01928758
Sponsor:  Milton S. Hershey Medical Center
Collaborator:  National Institute on Drug Abuse (NIDA)

15. Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)

ClinicalTrials.gov Identifier:  NCT02538042
Sponsor:  Francis McClernon
Collaborators:  National Institutes of Health (NIH) and National Institute on Drug Abuse (NIDA)

16. Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

ClinicalTrials.gov Identifier:  NCT02415270
Sponsor:  Milton S. Hershey Medical Center
Collaborators:  Food and Drug Administration (FDA), National Institutes of Health (NIH), and National Institute on Drug Abuse (NIDA)

17. Very-Low Nicotine Cigarettes and Non-Daily Smokers

ClinicalTrials.gov Identifier:  NCT02228824
Sponsor:  University of Pittsburgh
Collaborator:  National Cancer Institute (NCI)

18. Very Low Nicotine Cigarettes in Smokers With Schizophrenia

ClinicalTrials.gov Identifier:  NCT02019459
Sponsor:  Brown University
Collaborators:  National Institute on Drug Abuse (NIDA) and University of Pittsburgh

19. Very Low-Nicotine Cigarettes in Smokers With SUD

ClinicalTrials.gov Identifier:  NCT01989507
Sponsor/Collaborator:  Brown University

20. Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

ClinicalTrials.gov Identifier:  NCT02927847
Sponsor:  Maggie M. Sweitzer, PhD
Collaborator:  National Institute on Drug Abuse (NIDA)

21. Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Martketplace: Experiment 1

ClinicalTrials.gov Identifier:  NCT02951143
Sponsor:  Virginia Polytechnic Institute and State University

22. Concomitant Use of Very Low Nicotine Content Cigarettes and e-Cigarettes

ClinicalTrials.gov Identifier: NCT02964182
Sponsor: M.D. Anderson Cancer Center
Collaborator: National Institute on Drug Abuse (NIDA)

23. Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers (NicRed)

ClinicalTrials.gov Identifier: NCT02989038
Sponsor: Duke University
Collaborator: National Institute on Drug Abuse (NIDA)

24. Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder (RedNic)

ClinicalTrials.gov Identifier: NCT02990455
Sponsor: Battelle Memorial Institute

25. Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day

ClinicalTrials.gov Identifier: NCT03060083
Sponsor: University of Vermont